The syntheses of '%-ring labeled levamisole ([-)-2,3,5,6-tetrahydr0-6-phenyl[~'C-UL]imidazo(Z, 1b]thiole) from acetophenone-ring-UL-l'C in 5 steps plus resolution with a 7.5% overall yield, and %,-ring labeled tetramisole ([i]-2,3,5,6-tetrahydro-6-phenyif3 S ]imidaz0[2,?-bjthiazole) from benzene-'%,
Total Synthesis of Asymmetric Flavonoids: Development and Applications of 13C-Labelling
โ Scribed by Bastien Nay; Valerie Arnaudinaud; Joseph Vercauteren
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 56 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
## Abstract ^13^Cโ and ^14^Cโuniformly labelled catechol was synthesized from phenol in three steps. Phenol was derivatized with 2โchloroโ5โnitrobenzophenone in THF containing NaH, followed by __ortho__โhydroxylation with 35% aqueous H~2~O~2~ in sulphuric acid/glacial acetic acid solution, and by c
Aniline (IV), specifically 13C labeled in the 4-or in the 3,5-position (IVa and IVb), has been synthesized with 55% yield from I3C labeled pnitrophenol (11). The reduction of the NO2 group and the removal of the OH group was performed in one step by reduction and hydrogenolytic cleavage o f p-nitrop
## Abstract This report describes the synthesis of the ^13^Cโenriched and ^14^Cโlabelled title compound starting from isotopically labelled isovaleraldehyde.
## Abstract Phenyldithiane **3** is methylated with ^13^CH~3~I to give, through the thioacetal **4**, labelled acetophenone (**5**). NaOBrโcleavage to the title compounds **1** and **2** (65 % and 76 %, respectively) and their use in the preparation of the dibromocyclopropane **6** and the dibromoo