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Synthesis of 13C- and 14C-labelled catechol

✍ Scribed by Rong Ji; Andreas Schäffer

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 93 KB
Volume: 45
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.581

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✦ Synopsis

Abstract

^13^C‐ and ^14^C‐uniformly labelled catechol was synthesized from phenol in three steps. Phenol was derivatized with 2‐chloro‐5‐nitrobenzophenone in THF containing NaH, followed by ortho‐hydroxylation with 35% aqueous H~2~O~2~ in sulphuric acid/glacial acetic acid solution, and by cleavage with piperidine, giving an overall 80% yield with respect to phenol. Copyright © 2002 John Wiley & Sons, Ltd.

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