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Synthesis of 14C-labeled levamisole and 13C-labeled tetramisole

✍ Scribed by V. J. Feil

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 275 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199612)38:12<1071::aid-jlcr924>3.0.co;2-v

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✦ Synopsis

The syntheses of '%-ring labeled levamisole ([-)-2,3,5,6-tetrahydr0-6-phenyl[~'C-UL]imidazo(Z, 1b]thiole) from acetophenone-ring-UL-l'C in 5 steps plus resolution with a 7.5% overall yield, and %,-ring labeled tetramisole ([i]-2,3,5,6-tetrahydro-6-phenyif3 S ]imidaz0[2,?-bjthiazole) from benzene-'%, in 6 steps with a 9.0% overall yield are described.

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