๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Synthesis of 13C- and 14C-labeled 3-(dichloroacetyl)-5-(2-furanyl)-2,2-dimethyloxazolidine

โœ Scribed by Akbar Mehrsheikh

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
287 KB
Volume
38
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

โœฆ Synopsis

Synthesis of 3-(dichloroacetyl)-5-(2-furanyl)-2,2-dimethy~oxazolidine ( common name: furilazole) labeled with carbon-14 and carbon-13 are described. Two routes for the synthesis of labeled trimethylsilyl cyanide, a precursor to furilazole, are described. One method can be carried out on milligram scale and is suitable for a high specific activity preparation while the second method is suitable for preparation on gram scalc. Carbon-14 labeled furilazolc was obtain from isotopically labeled potassium cyanide in 5 steps with an overall yield of 28-34%.

๐Ÿ“œ SIMILAR VOLUMES

Synthesis of [3-D3]-, [3-13C]-, and [1,2
Synthesis of [3-D3]-, [3-13C]-, and [1,2-13C2]Propynes and Their Use for the Synthesis of [5-D3-Methyl]-, [5-13C-Methyl]-, and [5,6-13C2-2,5-Cyclohexadienyl]ubiquinones 3
โœ Claude Boullais; Christelle Rannou; Emmanuel Rรฉveillรจre; Charles Mioskowski ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 242 KB ๐Ÿ‘ 1 views

Three selectively labeled propynes were prepared either with deuterium or carbon-13 at position 3 and doubly labeled with carbon-13 at positions 1 and 2 by an alkylation reaction from the corresponding labeled or unlabeled monolithio acetylides and dimethylsulfates. Their lithiation with nBuLi gave