Synthesis of 3-(dichloroacetyl)-5-(2-furanyl)-2,2-dimethy~oxazolidine ( common name: furilazole) labeled with carbon-14 and carbon-13 are described. Two routes for the synthesis of labeled trimethylsilyl cyanide, a precursor to furilazole, are described. One method can be carried out on milligram sc
Synthesis of [1,2-13C]- and [2,3-13C]-labeled δ-aminolevulinic acid
✍ Scribed by Richard A. Bunce; Curtis L. Schilling III; Mario Rivera
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 406 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2135
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Three selectively labeled propynes were prepared either with deuterium or carbon-13 at position 3 and doubly labeled with carbon-13 at positions 1 and 2 by an alkylation reaction from the corresponding labeled or unlabeled monolithio acetylides and dimethylsulfates. Their lithiation with nBuLi gave
2-Ethoxy-1-methyl-5-pymlidinone (1) was reacted with ethyl [3,4-'3C2]acetoacetate (2) in the presence of T i c 4 to give ethyl [3,4-13C2]-2-( 1'-methyl-5'oxo-2'-pyrrolidinyl)-3-oxobutanoate (3) in 85% yield. Decarboethoxylation of ethyl [3,4-13C2]-2-( l'-methyl-5'-oxo-2'-pyrrolidiny1)-3-oxobutanoate