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Synthesis of [3-D3]-, [3-13C]-, and [1,2-13C2]Propynes and Their Use for the Synthesis of [5-D3-Methyl]-, [5-13C-Methyl]-, and [5,6-13C2-2,5-Cyclohexadienyl]ubiquinones 3

✍ Scribed by Claude Boullais; Christelle Rannou; Emmanuel Réveillère; Charles Mioskowski

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
242 KB
Volume
2000
Category
Article
ISSN
1434-193X

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✦ Synopsis

Three selectively labeled propynes were prepared either with deuterium or carbon-13 at position 3 and doubly labeled with carbon-13 at positions 1 and 2 by an alkylation reaction from the corresponding labeled or unlabeled monolithio acetylides and dimethylsulfates. Their lithiation with nBuLi gave the corresponding propynyllithium derivatives which reacted with dimethyl squarate to afford the corresponding

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