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Synthesis of 14C-labelled satigrel

✍ Scribed by Shigeru Tanaka; Youji Yamagishi; Kazutomi Kusano; Tsutomu Yoshimura

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 222 KB
Volume: 38
Category: Article
ISSN: 0022-2135
DOI: 10.1002/(sici)1099-1344(199605)38:5<435::aid-jlcr861>3.0.co;2-5

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✦ Synopsis

14C-Labelled satigrel, or 4-cyano-5-(4'-methoxy tring-U-14CI phenyl)-5-(4"methoxyphenyl)-4-pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4,4'-diniethoxy [ring-U-W ] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioactivity and radiochemical purity, as determined by radio-HPLC analysis, were 10.3 MBq(277.2 pCi)/rng and 98.8%, respectively.

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