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Synthesis of 3H and 14C labelled SCH 48461

✍ Scribed by D. Hesk; C. Bowlen; S. Hendershot; D. Koharski; P. McNamara; D. Rettig; S. Saluja

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
404 KB
Volume
38
Category
Article
ISSN
0022-2135

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✦ Synopsis

3H-Sch 47949, racemic 3H-Sch 48461, was prepared at a specific activity of 40 mCi/mmole by Pt catalysed exchange with tritiated water. 3H-Sch 48461 was prepared at a specific activity of 64.6 Ci/mmole by a Pd/C catalysed reduction of an olefinic intermediate. 14C-Sch 48461 was prepared in 8 steps from 14Cpotassium cyanide with an overall radiochemical yield of 18.5%.

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