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Synthesis of 4-13C and 3,5-13C labeled aniline as precursor of 13C - labeled monosubstituted benzenes

✍ Scribed by Helmut Rumpel; Hans-Heinrich Limbach

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 167 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580240302

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✦ Synopsis

Aniline (IV), specifically 13C labeled in the 4-or in the 3,5-position (IVa and IVb), has been synthesized with 55% yield from I3C labeled pnitrophenol (11). The reduction of the NO2 group and the removal of the OH group was performed in one step by reduction and hydrogenolytic cleavage o f p-nitrophenol-methanesulfonate ( I I I ) , prepared in 90% yield from (11). From (IV) a number of specifically I3C labeled monosubstituted benzenes C6H5Y ( Y = CN, Hal, N02) are easily accessible.

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