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Synthesis of [3-13C]-, [4-13C]- and [11-13C]-porphobilinogen

✍ Scribed by Prativa B. S. Dawadi; Els A. M. Schulten; Johan Lugtenburg

Publisher: John Wiley and Sons
Year: 2009
Tongue: French
Weight: 289 KB
Volume: 52
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1602

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✦ Synopsis

Abstract

[4‐^13^C]‐porphobilinogen 1a, [3‐^13^C]‐porphobilinogen 1b and [11‐^13^C]‐porphobilinogen 1c are prepared from [1‐^13^C]‐3‐(tetrahydropyran‐2′‐yloxy)‐propionaldehyde 2a, methyl [4‐^13^C]‐4‐nitrobutyrate 3b and [1‐^13^C]‐isocyanoacetonitrile 5c, respectively. The building blocks 2, 3 and 5 can be prepared efficiently in any isotopomeric form. Via base‐catalyzed condensation of these building blocks porphobilinogen can be enriched with ^13^C and ^15^N stable isotopes at any position and combination of positions. Copyright © 2009 John Wiley & Sons, Ltd.

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