𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of [2-13C]quinoline and [3-13C]quinoline

✍ Scribed by Michael A. Baldwin; G. John Langley

Publisher
John Wiley and Sons
Year
1985
Tongue
French
Weight
213 KB
Volume
22
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

CIQuinoline and [3-Clquinoline were synthesised by a five-step process starting from isatin.

Acetylation of isatin with acetyl chloride labelled in either the 1or 2-position, was followed by the Pfitzinger reaction to give 2-hydroxy-4-quinoline carboxylic acid labelled in the 2- or 3-position.

Decarboxylation by pyrolysis was followed by chlorination and reduction to the labelled quinolines.

The overall yield was approximately 20%

📜 SIMILAR VOLUMES

Synthesis of [3-13C]-, [4-13C]- and [11-
Synthesis of [3-13C]-, [4-13C]- and [11-13C]-porphobilinogen
✍ Prativa B. S. Dawadi; Els A. M. Schulten; Johan Lugtenburg 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 289 KB

## Abstract [4‐^13^C]‐porphobilinogen 1a, [3‐^13^C]‐porphobilinogen 1b and [11‐^13^C]‐porphobilinogen 1c are prepared from [1‐^13^C]‐3‐(tetrahydropyran‐2′‐yloxy)‐propionaldehyde 2a, methyl [4‐^13^C]‐4‐nitrobutyrate 3b and [1‐^13^C]‐isocyanoacetonitrile 5c, respectively. The building blocks 2, 3 and

Synthesis of [2-13C, 4-13C]-(2R,3S)-cate
Synthesis of [2-13C, 4-13C]-(2R,3S)-catechin and [2-13C, 4-13C]-(2R,3R)-epicatechin
✍ Pradeep K. Sharma; Min He; Leo J. Romanczyk Jr; Hagen Schroeter 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 196 KB

## Abstract The first synthesis of doubly labeled, [2‐^13^C, 4‐^13^C]‐(2__R__,3__S__)‐catechin 15 and [2‐^13^C, 4‐^13^C]‐(__2R__,3__R__)‐epicatechin 18 starting from labeled 2‐hydroxy‐4, 6‐bis(benzyloxy)acetophenone 3 and labeled 3, 4‐bis(benzyloxy)‐benzaldehyde 7 are described. Copyright © 2010 Jo