## Abstract New synthetic routes were developed for incorporating ^13^C into the oxazaphosphorine ring and nitrogen mustard functionality of cyclophosphamide metabolites. 1,2‐^13^C~2~‐Vinylbromide and ethylene oxide were used to synthesize 3,4‐^13^C~2~‐3‐butenyl N,N‐bis(2‐chloroethyl)phosphorodiami
Facile synthesis of [4-13C] butanoic acid and [4-13C] butanol
✍ Scribed by R. Van Der Laan; M. J. Moolenaar; H. De Koning
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- French
- Weight
- 256 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
Alkylation o f the dianion o f 3-(phenylsulfinyl)propanol with [ Cliodomethane and subsequent reductive fission of the sulfoxides gave [4-13C]butanol that was oxidized to give [4-13C]butanoic acid.
📜 SIMILAR VOLUMES
## Abstract [4‐^13^C]‐porphobilinogen 1a, [3‐^13^C]‐porphobilinogen 1b and [11‐^13^C]‐porphobilinogen 1c are prepared from [1‐^13^C]‐3‐(tetrahydropyran‐2′‐yloxy)‐propionaldehyde 2a, methyl [4‐^13^C]‐4‐nitrobutyrate 3b and [1‐^13^C]‐isocyanoacetonitrile 5c, respectively. The building blocks 2, 3 and
A simple, economic synthesis of C4,6-13C]nicotinic acid is described.