Synthesis of [4,6-13C]nicotinic acid
โ Scribed by Jill Barber
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 169 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
โฆ Synopsis
A simple, economic synthesis of C4,6-13C]nicotinic acid is described.
๐ SIMILAR VOLUMES
## Abstract Shikimicโ6โ^13^C acid, 43 ยฑ 5% enriched, was synthesized from 91% enriched aceticโ2โ^13^C acid via 91% enriched phosphoenolpyruvicโ3โ^13^c acid. The latter intermediate was condensed with erythroseโ4โphosphate by a cell free extract of __E__. __coli__ 83โ24.
Alkylation o f the dianion o f 3-(phenylsulfinyl)propanol with [ Cliodomethane and subsequent reductive fission of the sulfoxides gave [4-13C]butanol that was oxidized to give [4-13C]butanoic acid.
## Abstract The synthesis of [4aโ^13^C]โ6โmethyltetrahydropterin, a synthetic cofactor for phenylalanine hydroxylase, is described. [2โ^13^C]โethyl bromoacetate was converted in four steps to [5โ^13^C]โ2,4โdiaminoโ6โhydroxypyrimidine in 86% yield. The latter was nitrosated, reduced, condensed with
## Abstract The synthesis of [1,3,5โ^13^C~3~]โ and [2,4,6,7โ^13^C~4~]benzoic acid (5a and 5b) from [2โ^13^C]โ and [3โ^13^C]sodium pyruvate (1a and 1b), for __in vitro__ and __in vivo__ tracer studies using ^13^C nuclear magnetic resonance (NMR) spectroscopy, is reported. After condensation of 1 to