## Abstract The chemical synthesis of 99% enriched D(โ)โ[1,7โ^13^C~2~]shikimic acid from [1,2โ^13^C~2~]acetate in 25% overall yield is described. A twoโcarbon phosphonate synthon was prepared from [1,2โ^13^C~2~]acetate and used in the shikimate synthesis of Fleet and coworkers.
Synthesis of Shikimic-6-13C acid
โ Scribed by Ulrich Hollstein; David L. Mock; Randy R. Sibbitt; Uta Roisch; Franz Lingens
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 310 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
Shikimicโ6โ^13^C acid, 43 ยฑ 5% enriched, was synthesized from 91% enriched aceticโ2โ^13^C acid via 91% enriched phosphoenolpyruvicโ3โ^13^c acid. The latter intermediate was condensed with erythroseโ4โphosphate by a cell free extract of E. coli 83โ24.
๐ SIMILAR VOLUMES
Enantiospecific Synthesis of (-)-5-epi-Shikimic Acid and (-)-Shikimic Acid. -The key step in the synthesis of the title compounds (XI) and (XVI) is the intramolecular cycloaddition of the nitrones (V) and (XIV). -
A simple, economic synthesis of C4,6-13C]nicotinic acid is described.
## Abstract A oneโpot synthesis of (ยฑ)โ(ring ^13^C~6~)โmandelic acid is reported. [Ring ^13^C~6~]โbenzaldehyde was cyanosilylated with trimethylsilyl cyanide (TMSCN)/Znl~2~. The resulting cyanosilylated adduct was hydrolyzed with concentrated hydrochloric acid without purification. The workup invol