✦ LIBER ✦

A one-pot synthesis of (±)-(ring 13C6)-mandelic acid

✍ Scribed by Sarath R. Sirimanne; Donald G. Patterson Jr.

Publisher: John Wiley and Sons
Year: 1993
Tongue: French
Weight: 269 KB
Volume: 33
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580330808

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✦ Synopsis

Abstract

A one‐pot synthesis of (±)‐(ring ^13^C~6~)‐mandelic acid is reported. [Ring ^13^C~6~]‐benzaldehyde was cyanosilylated with trimethylsilyl cyanide (TMSCN)/Znl~2~. The resulting cyanosilylated adduct was hydrolyzed with concentrated hydrochloric acid without purification. The workup involves evaporation to dryness and extraction of the (±)‐(ring ^13^C~6~)‐mandelic acid with hot benzene. After one crystallization, the synthesis produced an overall yield of 65% of (±)‐(ring ^13^C~6~)‐mandelic acid that was about 98% pure by HPLC with UV detection.

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