𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A synthesis of porphobilinogen-11-13C

✍ Scribed by Graciela Buldain; Aldonia Valasinas

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
214 KB
Volume
19
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Porphobilinogen‐11‐^13^C was prepared by using benzyl 3‐(β‐methoxycarbonylethyl)‐4‐ (methoxycarbonylmethyl)‐2‐pyrrolecarboxylate as a starting material. A Vilsmeier‐Haak formylation with N,N′‐dimethylform‐^13^C‐amide gave the 2‐formylpyrrole, which was transformed into its oxime, and the latter was hydrogenated to the hydrochioride of 5‐carboxyporphobilinogen dimethyl ester. The hydrochloride cyclized to 5‐carboxyporphobilinogen lactam at pH 9, and the latter was first decarboxylated and then saponified to give the title compound.

📜 SIMILAR VOLUMES

Synthesis of [3-13C]-, [4-13C]- and [11-
Synthesis of [3-13C]-, [4-13C]- and [11-13C]-porphobilinogen
✍ Prativa B. S. Dawadi; Els A. M. Schulten; Johan Lugtenburg 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 289 KB 👁 1 views

## Abstract [4‐^13^C]‐porphobilinogen 1a, [3‐^13^C]‐porphobilinogen 1b and [11‐^13^C]‐porphobilinogen 1c are prepared from [1‐^13^C]‐3‐(tetrahydropyran‐2′‐yloxy)‐propionaldehyde 2a, methyl [4‐^13^C]‐4‐nitrobutyrate 3b and [1‐^13^C]‐isocyanoacetonitrile 5c, respectively. The building blocks 2, 3 and

1H, 3H and 13C NMR studies on porphobili
1H, 3H and 13C NMR studies on porphobilinogen
✍ J. N. S. Evans; P. E. Fagerness; N. E. Mackenzie; A. I. Scott 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 470 KB 👁 1 views
Synthesis of [8,9,10,11-13C4]leukotriene
Synthesis of [8,9,10,11-13C4]leukotriene C4
✍ Mark J. Raftery; Simon J. Gaskell 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 273 KB

## Abstract A “one pot” reduction of ethyl [1,2‐^13^C~2~]bromoacetate with diisobutylaluminium hydride in dichloromethane, followed by reaction with triphenylphosphine, then triethylamine, yields [1,2‐^13^C~2~]formylmethylenetriphenylphosphorane. Consecutive Wittig reactions of [1,2‐^13^C~2~] formy