Synthesis of [11C]/[13C]Acrylamides by Palladium-Mediated Carbonylation
✍ Scribed by Jonas Eriksson; Ola Åberg; Bengt Långström
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 159 KB
- Volume
- 2007
- Category
- Article
- ISSN
- 1434-193X
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## Abstract The urea moiety is present in many biologically active compounds and thus an attractive target for ^11^C‐labelling. To extend the scope of the rhodium(I)‐mediated carbonylative cross‐coupling reaction between an azide and an amine and investigate its tolerance for functional groups, we
11 C]Hydroxyurea has been successfully labelled using [ 11 C]carbon monoxide at low concentration. The decay-corrected radiochemical yield was 38 AE 3%, and the trapping efficiency of [ 11 C]carbon monoxide in the order of 90 AE 5%. This synthesis was performed by a rhodium-mediated carbonylation