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The synthesis of serotonin 14C-labelled in the ring (5-hydroxytryptamine-3-14C)

✍ Scribed by D. Keglevič; L. Stančič

Publisher: John Wiley and Sons
Year: 1967
Tongue: French
Weight: 289 KB
Volume: 3
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590030210

No coin nor oath required. For personal study only.

✦ Synopsis

For metabolic studies in this Laboratory, 5-hydroxytryptamine (serotonin) labelled with I4C in the pyrrole part of the indole ring was required. Previous attempts to reach this compound through Madelung cyclization of 3-benzyloxy--6-formylaminotoluene failed (I), although this way proved to be successful for the preparation of unsubstituted indole-2J4C (2). A number of methods leading to 5-hydroxytryptamine were then compared and the following synthetic pathway starting with pyruvic acid-3-14C was elaborated on onemillimole scale : Rl=H R, =CH3 lii R, =CO,CH,

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