14C-Labelled satigrel, or 4-cyano-5-(4'-methoxy tring-U-14CI phenyl)-5-(4"methoxyphenyl)-4-pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4,4'-diniethoxy [ring-U-W ] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioacti
The synthesis of [14C] labelled Eutypine
✍ Scribed by Eric Defrancq; Raffaele Tabacchi
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- French
- Weight
- 302 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The synthesis of radiolabelled 4‐hydroxy‐3‐(3‐methyl‐3‐buten‐1‐ynyl) benzaldehyde (eutypine 1), a phytotoxic compound isolated from the culture media of the fungus Eutypa lata, responsible for vineyard die‐back, is described. The radioisotope ^14^C was introduced via a Wittig reaction using [^14^C] methyl‐iodide as precursor.
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The synthesis of 14C-labelled crotamiton, which is a fungicide, an insecticide as well as a scabicide is described. Starting from 2-bromonitrobenzene and Cu14CN, 2-toluidine, labelled with 14C at the methyl group was prepared by the following sequence of reactions : N O ~-C ~H L + -~~C O O H
## Abstract [^14^C]Aminoguanidine was synthesized by the reaction of hydrazine sulphate with barium [^14^C]cyanamide in a one‐step synthesis, and conveniently isolated by crystallization as the bicarbonate salt. The yield was 32%.
## Abstract ^14^C‐labelled (+)‐limonene was conveniently prepared by the Wittig reaction of (+)‐1‐methyl‐4‐acetylcyclohexene with methyl‐^14^C‐triphenylphosphonium iodide.
## Department of Drug Metabolism, Janssen Phamceutica Butoxyethoxyethanoll. an organic solvent used as carrier in the levamisole pour-on formulation, was synthesized a Hakosza etherification of l-%labelled brornobutano with mono tetrahydropyranyl (T.H.P.) protected diethylene glycol and subsequent