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Synthesis of 14C-labelled butoxyethoxyethanol

✍ Scribed by J. B. A. Thijssen; C. G. M. Janssen; W. L. M. Verluyten; J. J. P. Heykants

Publisher: John Wiley and Sons
Year: 1986
Tongue: French
Weight: 189 KB
Volume: 23
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580230213

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✦ Synopsis

Department of Drug Metabolism, Janssen Phamceutica

Butoxyethoxyethanoll. an organic solvent used as carrier in the levamisole pour-on formulation, was synthesized a Hakosza etherification of l-%labelled brornobutano with mono tetrahydropyranyl (T.H.P.) protected diethylene glycol and subsequent removal of the T.H.P. protecting group. The compounds' synthetic yield was 88.8 X; it had a spectflc activity of 32.5 mCi/rmnol. The reaction product was radiochemically pure (99.6 $1 according to high-performance liquid chromatography and thin-layer chromatography in three solvent systems.

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