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Synthesis of [14C]-l-tryptophan and [14C]-5′-hydroxy-l-tryptophan labeled in the carboxyl group

✍ Scribed by E. Boroda; R. Kański; M. Kańska

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
88 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of selectively ^14^C‐labeled l‐tryptophan and its derivative 5‐hydroxy‐l‐tryptophan using chemical and multienzymatic methods is reported. The mixture containing [1‐^14^C[‐dl‐alanine, indole or 5‐hydroxyindole has been converted to [1‐^14^C]‐l‐tryptophan or 5′‐hydroxy‐[1‐^14^C]‐l‐tryptophan, respectively, in a one‐pot multienzymatic reaction using four enzymes: d‐amino acid oxidase, catalase, glutamic‐pyruvic transaminase and tryptophanase. Copyright © 2003 John Wiley & Sons, Ltd.

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