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Synthesis of carbon-14 labeled [1-14C]-, and [2-14C]-L-tyrosine

✍ Scribed by W. Augustyniak; R. Kański; M. Kańska

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
96 KB
Volume
44
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Two labeled isotopomers of L‐tyrosine, L‐Tyr, have been synthesized using specific properties of the enzymes phenylanine ammonia lyase, PAL, and L‐phenylalanine hydroxylase. In an intermediate step [1‐^14^C]‐, and [2‐^14^C]‐L‐phenylalanine, L‐Phe, have been obtained from [1‐^14^C]‐, and [2‐^14^C]cinnamic acid, prepared from potassium [^14^C]cyanate or [2‐^14^C]malonic acid, and by addition of ammonia in the presence of enzyme PAL. The labeled isotopomers of L‐Phe have been converted into [1‐^14^C]‐, and [2‐^14^C]‐L‐Tyr using the enzyme L‐phenylalanine hydroxylase. Copyright © 2001 John Wiley & Sons, Ltd.

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