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Synthesis of carbon-14 labelled acetaminophen (4-hydroxyphenylacetamide, carbonyl-14C)

✍ Scribed by S. Stavchansky; P. Wu

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
120 KB
Volume
14
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A simple and convenient method for the condensation of paminophenol (I) with ^14^C‐acetic anhydride (II) yields up to 76% of ^14^C‐labelled 4‐hydroxyphenylacetamide (carbonyl‐^14^C) (III). Typical synthesis time is 60 minutes. Radioactive yield is 51%, and specific activity is 0.22 μCi/mg.

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