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Synthesis of carbon-14 labelled gemifloxacin

✍ Scribed by Hyun Il Shin; Jong Gill Rim; Ki Seung Lee; Young Seok Kim; Do Hyun Nam; Hyun Ik Shin; Jay Hyok Chang; Chang Young Oh; Won Hun Ham

Publisher: John Wiley and Sons
Year: 2004
Tongue: French
Weight: 112 KB
Volume: 47
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.866

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✦ Synopsis

Abstract

A new antibacterial agent gemifloxacin was labelled with carbon‐14 for studies of pharmacokinetics and metabolism, the label was located in position 3 of the quinolone ring system. The overall radiochemical yield of the 14‐step synthesis, starting from [2‐^14^C]sodium acetate was 16.6%, and the radiochemical purity 97.5%. Copyright © 2004 John Wiley & Sons, Ltd.

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