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Synthesis of carbon-14-labelled pyronaridine tetraphosphate

✍ Scribed by Sang Hyun Park; Kannampalli Pradeep; Seung Ho Jang

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
153 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Pyronaridine tetraphosphate is an antimalarial drug which is currently being widely investigated for use in the chemotherapy of malaria. We synthesized carbon‐14‐labelled pyronaridine tetraphosphate (^14^C‐PNDP, 5) by a classical method and also by a microwave irradiation technique for use in biodistribution studies and pharmacokinetic analysis. The application of microwave irradiation facilitated the use of high temperatures resulting in decreased reaction time and employed far less amount of the starting material when compared with the classical method. ^14^C‐PNDP (5) thus synthesized had a chemical purity of >99% as determined by high‐performance liquid chromatography (HPLC) and a radiochemical purity of >99% as determined by radio‐HPLC. Copyright © 2007 John Wiley & Sons, Ltd.

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