✦ LIBER ✦

An improved synthesis of Carbon-14 labelled carboxylic acids from Carbon-14 labelled amino acids

✍ Scribed by T. V. Ramamurthy; S. Ravi; K. V. Viswanathan

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 223 KB
Volume: 25
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580250802

No coin nor oath required. For personal study only.

✦ Synopsis

Various Carbon-I4 l a b e l l e d amino acids i n c l u d i n g t h e a r o m a t i c ones viz., t y r o s i n e , phenylalanine and t r y p t o p h a n are converted t o t h e corresponding c a r b o x y l i c acids i n high y i e l d (70 -9M) on a micromolar scale s y n t h e s i s l y r e a c t i o n w i t h hydroxylamine-0-sulphonic acid and I n a s h o r t r e a c t i o n t i m e .

The improvement i n y i e l d has been achieved by u s i n g aqueous alcohol as s o l v e n t i n l i e u of water alone as t h e medium o f r e a c t i o n .

📜 SIMILAR VOLUMES

Small-scale degradation of carbon-14 lab

Small-scale degradation of carbon-14 labelled carboxylic acids. II. Complete degradation of carbon-14 labelled propionic and n-butyric acids

✍ A. B. Susan; R. F. Nystrom 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 351 KB

A chemical degradation and radioassay procedure is described for jinding the radioactivity in each carbon-atom of carbon-I4 labelled propionic and n-butyric acids. This method has been tested with suitably labelled compounds and found to be isotopically reliable. ## INTRODUCTION. The Schmidt (1-8

An efficient synthesis of carbon-14 labe

An efficient synthesis of carbon-14 labelled vigabatrin

✍ Harpal S. Gill 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 229 KB

Vigabatrin-[6-14C] ((R,S)-4-amino-5-hexenoic-[6-14C] acid) was synthesized by employing Wittig condensation of 1-(1- butenyl)-2-oxo-5-pyrolidinecarboxaldehyde with methyl-[ 14C]-triphenylphosphonium iodide as the key step. The synthetic sequence involved 3 steps and produced the title compound in 70

Synthesis of carbon-14 and deuterium lab

Synthesis of carbon-14 and deuterium labeled valproic acids

✍ Vasant V. Ranade; Arthur Alter 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 366 KB

## Abstract Valproic acid and sodium valproate labeled with carbon‐14 in the 2‐position were synthesized. Deuterium labeled valproic acid was also synthesized and the extent of deuterium incorporation was determined by several analytical methods.

Small-scale degradation of carbon-14 lab

Small-scale degradation of carbon-14 labelled carboxyl acids. III. Degradation of acetic acid−14C

✍ R. Numrich; R. F. Nystrom 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 295 KB

A simple atid rapid degradation procedure is described jor the determination of the millirnolar radioactivity of the methyl and carboxyl groups in carbon-14 labelled acetic acid, The barium salt of the acid is converted to barium carbonate and carbon dioxide by using pyrolysis in tandem wit17 combus

synthesis of 14C-labelled tranexamic aci

synthesis of 14C-labelled tranexamic acid [trans-amino-(14C-methyl)-cyclohexane carboxylic acid]

✍ Jan Lundström; Gertrud Westin-Sjödahl; N. Åke Jönsson 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 195 KB

Small-scale degradation of carbon-14 lab

Small-scale degradation of carbon-14 labelled carboxylic acids. I. Modification of the hunsdiecker reaction

✍ A. B. Susan; R. F. Nystrom 📂 Article 📅 1971 🏛 John Wiley and Sons 🌐 French ⚖ 254 KB

## Abstract A modified Hunsdiecker reaction is described for the degradation of the silver salts of acetic acid‐1−^14^C, acetic acid‐2−^14^C, propionic acid‐1−^14^C, propionic acid‐3−^14^C, n‐butyric acid‐1−^14^C and n‐butyric acid‐2−^14^C to carbon dioxide, silver bromide and an organic bromide co