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Small-scale degradation of carbon-14 labelled carboxylic acids. I. Modification of the hunsdiecker reaction

✍ Scribed by A. B. Susan; R. F. Nystrom

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
254 KB
Volume
7
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A modified Hunsdiecker reaction is described for the degradation of the silver salts of acetic acid‐1−^14^C, acetic acid‐2−^14^C, propionic acid‐1−^14^C, propionic acid‐3−^14^C, n‐butyric acid‐1−^14^C and n‐butyric acid‐2−^14^C to carbon dioxide, silver bromide and an organic bromide containing one less carbon atom than the acid, on a 0.5 to 10 millimole scale. This reaction is performed by allowing the silver salt of a carbon‐14 labelled acid to react with bromine vapor in a sealed tube. Then the separation, purification and determination of the amount of each degradation product is accomplished by use of high vacuum techniques. Finally, the products which are obtained in a radiochemically pure form are analyzed for radioactivity by liquid scintillation counting.

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