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Small-scale degradation of carbon-14 labelled carboxyl acids. III. Degradation of acetic acid−14C

✍ Scribed by R. Numrich; R. F. Nystrom

Publisher
John Wiley and Sons
Year
1971
Tongue
French
Weight
295 KB
Volume
7
Category
Article
ISSN
0022-2135

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✦ Synopsis

A simple atid rapid degradation procedure is described jor the determination of the millirnolar radioactivity of the methyl and carboxyl groups in carbon-14 labelled acetic acid, The barium salt of the acid is converted to barium carbonate and carbon dioxide by using pyrolysis in tandem wit17 combustion at 5000 C.

A common procedure for establishing the labelling pattern in acetic acid-I4C involves the pyrolysis of the barium salt to barium carbonate and acetone, which is converted to iodoform This paper describes the development of a rapid, improved and isotopically reliable process for finding the distribution of label in acetic acid-'*C. The Pregl method for the determination of carbon and hydrogen has been modified for the degradation of carbon-14 labelled barium acetate samples.

Pyrolysis is accomplished by heating the barium acetate at 500° C first in a helium and then in an oxygen atmosphere. The major products are barium

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