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An efficient synthesis of carbon-14 labelled vigabatrin

✍ Scribed by Harpal S. Gill

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 229 KB
Volume: 36
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580360504

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✦ Synopsis

Vigabatrin-[6-14C] ((R,S)-4-amino-5-hexenoic-[6-14C] acid) was synthesized by employing Wittig condensation of 1-(1- butenyl)-2-oxo-5-pyrolidinecarboxaldehyde with methyl-[ 14C]-triphenylphosphonium iodide as the key step. The synthetic sequence involved 3 steps and produced the title compound in 70% overall yield with a radiochemical purity of 100%.

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