𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of carbon-14 labeled vigabatrin

✍ Scribed by Albert J. Schuster; Eugene R. Wagner

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
191 KB
Volume
33
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Carbon‐14 labeled vigabatrin was synthesized in 5 steps from 5‐hydroxymethyl‐2‐pyrrolidone tosylate and NaCN‐[^14^C]. A key step involved reduction of the resulting nitrile in the presence of excess dimethylamine to give the dimethylamino‐ethyl 2‐pyrrolidone derivative in one step. This afforded an overall radiochemical yield of 22% and radiochemical purity greater than 98%.

📜 SIMILAR VOLUMES

An efficient synthesis of carbon-14 labe
An efficient synthesis of carbon-14 labelled vigabatrin
✍ Harpal S. Gill 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 229 KB

Vigabatrin-[6-14C] ((R,S)-4-amino-5-hexenoic-[6-14C] acid) was synthesized by employing Wittig condensation of 1-(1- butenyl)-2-oxo-5-pyrolidinecarboxaldehyde with methyl-[ 14C]-triphenylphosphonium iodide as the key step. The synthetic sequence involved 3 steps and produced the title compound in 70

Synthesis of carbon-14 labeled disuprazo
Synthesis of carbon-14 labeled disuprazole
✍ W. T. Stolle; J. C. Sih; R. S. P. Hsi 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 365 KB 👁 1 views

This report describes the synthesis of carbon-14 labeled title compound from [14C]CS2. The substituted benzimidazole was labeled at the C-2 position of the benzimidazole moiety.

Synthesis of carbon-14 labeled capsaicin
Synthesis of carbon-14 labeled capsaicin
✍ Richard S. Bodine; Ping-Lu Chien 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 224 KB

The synthesis and purification of carbon-14 labeled capsaicin are described.

Synthesis of carbon-14 labeled clomiphen
Synthesis of carbon-14 labeled clomiphene
✍ P. Narasimha Rao; James W. Cessac 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 French ⚖ 388 KB

Clomiphene, 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy~-N.N- diethylethanamine, an antiestrogen, is a nonsteroidal triphenylethylene derivative. For the successful synthesis of carbon-14 labeled clomiphene it is essential to have a free radical inhibitor in the reaction medium.

Synthesis of carbon-14 labeled dibutylti
Synthesis of carbon-14 labeled dibutyltin dichloride
✍ Anita Lewin; Robert Jeffcoat; Bertold Berrang 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 100 KB

## Abstract This report describes the preparation of carbon‐14 labeled dibutyltin dichloride from carbon‐14 labeled barium carbonate in 30% overall radiochemical yield. The key steps were (a) the preparation of carbon‐14 labeled butyl bromide from carbon‐14 labeled barium carbonate via carbon‐14 la