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Synthesis of [Carbonyl-14c] labeled carbonate and carbamate esters

✍ Scribed by Munir N. Nassar; Bushra J. Agha; George A. Digenis

Publisher
John Wiley and Sons
Year
1986
Tongue
French
Weight
344 KB
Volume
23
Category
Article
ISSN
0022-2135

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✦ Synopsis

A two-step s y n t h e s i s of t h r e e carbonate and f o u r carbamate esters l a b e l e d a t t h e carbonyl with c a r n-14 i s described. The method u t i l i z e s t h e r e a d i l y a v a i l a b l e [' %I -phosgene which i s f i r s t converted t o an i s o l a b l e [14C] -labeled a l k y l o r a r y l chloroformate and subsequently r e a c t e d with t h e a p p r o p r i a t e a l c o h o l o r amine t o give t h e corresponding ester.

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