✦ LIBER ✦

Synthesis of 14C-labelled fluphenazine esters

✍ Scribed by G. Zólyomi; I. Tóth; L. Toldy

Publisher: John Wiley and Sons
Year: 1982
Tongue: French
Weight: 373 KB
Volume: 19
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580190607

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✦ Synopsis

Abstract

Fluphenazine labelled with ^14^C at the 3‐propyl position was prepared. Starting from K^14^CN, 3‐chloropropyl p‐toluenesulfonate (7) was synthesized via 3‐chloropropionic acid (4) intermediate and coupled with 2‐trifluoromethylphenothiazine. The phenothiazine derivative (8) obtained was converted into 1a, from which various long acting esters (1b, 1c, 1d) of labelled fluphenazine were prepared for comparative pharmacokinetic studies.

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