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Synthesis of carbon-14 labeled 1,4-benzodiazepnies. II.(1) diazepam-14C, demethyldiazepam-14C, and ketazolam-14C

✍ Scribed by Richard S. P. Hsi

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
287 KB
Volume
10
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Diazepam‐^14^C and demethyldiazepam‐^14^C are synthesized from glycine‐1‐^14^C. Addition of diketene to diazepam‐^14^C leads to ketazolam‐^14^C. The reaction conditions for the formation of ketazolam from diazepam is studied using high‐pressure liquid chromatography in conjunction with radioactivity determinations.

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