𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of α-[14C]methyl and α-[3H]methyl-L-tryptophan

✍ Scribed by T. K. Venkatachalam; S. Mzengeza; M. Diksic

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
383 KB
Volume
33
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The title compounds were synthesized starting from dimethyl (2S,3aR,8aS)‐(+)‐8‐(phenylsulfonyl)hexahydrophyrrolo[2,3‐b]indole‐1,2‐dicarboxylate. This compound on treatment with LDA followed by reaction with [^14^C]methyl iodide or [^3^H]methyl iodide gave the methyl substituted derivative which on treatment with trifloroacetic acid followed by hydrolysis with alkali gave the desired α‐[~14~C]methyl‐ or [^3^H]methy‐L‐tryptophan, respectively, in 50‐60% radiochemical yield.

📜 SIMILAR VOLUMES

Human brain serotonin synthesis capacity
Human brain serotonin synthesis capacity measured in vivo with α-[C-11]methyl-L-tryptophan
✍ Diane C. Chugani; Otto Muzik; Pulak Chakraborty; Thomas Mangner; Harry T. Chugan 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB

Local cerebral serotonin synthesis capacity was measured with ␣- [C-11]methyl-L-tryptophan ([C-11]AMT) in normal adult human brain (n ϭ 10; five males, five females; age range, 18-38 years, mean 28.3 years) by using positron emission tomography (PET). [C-11]AMT is an analog of tryptophan, the precur

Further investigation on the radiosynthe
Further investigation on the radiosynthesis of α-[11C]methyl-tryptophan
✍ Makiko Suehiro; Hayden T. Ravert; Alan A. Wilson; Ursula Scheffel; Robert F. Dan 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 415 KB

## Abstract Improved procedures for the radiosynthesis of α‐[^11^C]methyltryptophan and α‐[^11^C]methyl‐tryptophan methyl ester were studied. Following α‐deprotonation of tryptophan methyl ester benzaldimine with LDA, 60 – 80% of no carrier added [^11^C]iodomethane was incorporated in 5 minutes at

Synthesis of 14C-methyl benzyl nitrosami
Synthesis of 14C-methyl benzyl nitrosamine and methyl 14C-benzyl nitrosamine
✍ Paul L. Skipper 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 201 KB

The synthesis of k -l a b e l l e d methyl benzyl n i t r o s - amine is reported. Two fonns were prepared, one with a l a b e l i n the methyl group and one with l a b e l i n the methylene portion of t h e benzyl group. a c t i v i t i e s were approximately 5 mCi/mmol.