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Further investigation on the radiosynthesis of α-[11C]methyl-tryptophan

✍ Scribed by Makiko Suehiro; Hayden T. Ravert; Alan A. Wilson; Ursula Scheffel; Robert F. Dannals; Henry N. Wagner Jr.

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
415 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Improved procedures for the radiosynthesis of α‐[^11^C]methyltryptophan and α‐[^11^C]methyl‐tryptophan methyl ester were studied. Following α‐deprotonation of tryptophan methyl ester benzaldimine with LDA, 60 – 80% of no carrier added [^11^C]iodomethane was incorporated in 5 minutes at 27 – 30°C. After HPLC purification, radiochemically pure α‐[^11^C]methyl‐tryptophan or its methyl ester was produced with minimum chemical contamination from tryptophan. The [^11^C]methyl‐tryptophan synthesized, however, was found to be a racemate.

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