✦ LIBER ✦

A rapid one-step radiosynthesis of the β-amyloid imaging radiotracer N-methyl-[11C]2-(4′-methylaminophenyl)-6-hydroxybenzothiazole ([11C]-6-OH-BTA-1)

✍ Scribed by Alan A. Wilson; Armando Garcia; Alexandra Chestakova; Hank Kung; Sylvain Houle

Publisher: John Wiley and Sons
Year: 2004
Tongue: French
Weight: 94 KB
Volume: 47
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.854

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✦ Synopsis

Abstract

The promising β‐amyloid PET imaging agent, [^11^C]‐6‐OH‐BTA‐1, has been radiolabelled in one step using [^11^C]‐methyl triflate. No protection of the 6‐hydroxy group is required, greatly simplifying the synthetic method. The reaction may be carried out in solution or by the captive solvent ‘loop’ method. Copyright © 2004 John Wiley & Sons, Ltd.

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