𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of tritium labeled isotopomers of L-tyrosine

✍ Scribed by W. Augustyniak; P. Suchecki; J. Jemielity; R. Kański; M. Kańska

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
108 KB
Volume
45
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The synthesis of four selectively labeled isotopomers of L‐tyrosine, (L‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐^3^H]‐, [2′,6′‐^3^H~2~]‐, [3R‐^3^H]‐ and [3S‐^3^H]‐ have been synthesized using a combination of chemical and enzymatic methods. The labeled isotopomers of L‐Phe have been converted into [2 ‐^3^H]‐, [2′,6′‐^3^H~2~]‐, [3R‐^3^H]‐, and [3S‐^3^H]‐L‐Tyr by using the enzyme L‐phenyl‐alanine 4′‐monooxygenase. Copyright © 2002 John Wiley & Sons, Ltd.

📜 SIMILAR VOLUMES

Enzymatic synthesis of tritium-labelled
Enzymatic synthesis of tritium-labelled isotopomers of L-DOPA
✍ M. Kozłowska; R. Kański; M. Kańska 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 107 KB 👁 1 views

The synthesis of two isotopomers of l-DOPA labelled selectively with tritium is reported. In the intermediate step [3S-3 H]-, and [3 0 ,5 0 -3 H 2 ]-l-tyrosine, have been obtained using a combination of chemical and enzymatic methods. The labelled isotopomers of l-tyrosine, l-Tyr, have been converte

Synthesis of tritium labelled [2′,6′]-L-
Synthesis of tritium labelled [2′,6′]-L-tyrosine
✍ W. Augustyniak; R. Kański; M. Kańska 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 85 KB

## Abstract The synthesis of a specifically ring labelled isotopomer of L‐tyrosine, (L‐Tyr), using a combination of chemical and enzymatic methods is reported. The tritium labelled [2′,6′]‐L‐Tyr has been synthesized __via__ catalytic exchange of phenol with tritiated water in the presence of K~2~Pt

Enzymatic synthesis of tritium-labelled
Enzymatic synthesis of tritium-labelled isotopomers of histamine
✍ E. Panufnik; R. Kański; M. Kańska 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 92 KB 👁 1 views

## Abstract Three tritium‐labelled isotopomers of histamine (HA) have been synthesized using combined chemical and enzymatic methods. In the first step the tritium‐labelled isotopomers of histidine have been obtained by catalysed exchange with tritiated water. These intermediates have been converte

Synthesis of isotopomers of dopamine lab
Synthesis of isotopomers of dopamine labeled with deuterium or tritium
✍ M. Pająk; M. Kańska 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 127 KB

## Abstract The synthesis of four isotopomers of dopamine labeled with deuterium or tritium is reported. The ring labeled [2′,5′,6′‐^2^H~3~]‐, and [2′,5′,6′‐^3^H~3~]‐dopamine were obtained using acid catalyzed isotopic exchange between dopamine and heavy or tritiated water respectively. Two selecti

Enzymatic synthesis of isotopomers of ty
Enzymatic synthesis of isotopomers of tyramine labeled with deuterium and tritium
✍ Edyta Panufnik; Marianna Kañska 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 116 KB 👁 1 views

The combined chemical and enzymatic methods of synthesis of five isotopomers of l-tyrosine, l-Tyr, and their derivatives, i.e. corresponding isotopomers of tyramine (TA), labeled with deuterium and tritium have been reported. Two-step synthesis consists with introduction of deuterium or tritium labe

Synthesis of tritium labeled O-ethyl-D-t
Synthesis of tritium labeled O-ethyl-D-tyrosine and phenylalanine
✍ Scott W. Landvatter; J. Richard Heys; Stephen G. Senderoff 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 337 KB

Two amino acids, 1-BOC-0-ethyl-P-tyrosine and 1-BOC-phenylalanine, have been synthesized in tritium labeled form via exchange with tritium gas over catalyst on an unlabeled precursor and dehydrohalogenation on an iodinated precursor respectively. The tyrosine derivative has been obtained in specifi