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Synthesis of isotopomers of dopamine labeled with deuterium or tritium

✍ Scribed by M. Pająk; M. Kańska

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
127 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The synthesis of four isotopomers of dopamine labeled with deuterium or tritium is reported. The ring labeled [2′,5′,6′‐^2^H~3~]‐, and [2′,5′,6′‐^3^H~3~]‐dopamine were obtained using acid catalyzed isotopic exchange between dopamine and heavy or tritiated water respectively. Two selectively labeled isotopomers, i.e. [1R‐^2^H]‐, and [1R‐^3^H]‐dopamine were synthesized by enzymatic decarboxylation of L‐DOPA using the enzyme tyrosine decarboxylase (EC 4.1.1.25) from Streptococcus faecalis. Copyright © 2006 John Wiley & Sons, Ltd.

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