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Enzymatic synthesis of tritium-labelled isotopomers of histamine

✍ Scribed by E. Panufnik; R. Kański; M. Kańska

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
92 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Three tritium‐labelled isotopomers of histamine (HA) have been synthesized using combined chemical and enzymatic methods. In the first step the tritium‐labelled isotopomers of histidine have been obtained by catalysed exchange with tritiated water. These intermediates have been converted into [1S‐^3^H]‐HA, [1R‐^3^H]‐HA and [2′,4′,1S,‐^3^H~3~]‐HA using the enzyme histidine decarboxylase (HDC, EC 4.1.1.22) from Lactobacillus 30a. Copyright © 2004 John Wiley & Sons, Ltd.

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