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Enzymatic synthesis of N-methylhistamine labeled with deuterium and tritium

✍ Scribed by J. Šamonina; M. Kańska

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
154 KB
Volume
52
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The isotopomers of N^π^‐methylhistamine (πMeHA) and N^τ^‐methylhistamine (τMeHA) labeled with deuterium and tritium at the α‐carbon atom of the side chain were obtained using the enzyme histidine decarboxylase (HDC, EC 4.1.1.22) from Lactobacillus 30a. The deuterium labeled isotopomers [(αR)‐^2^H]‐πMeHA and [(αR)‐^2^H]‐τMeHA were synthesized by enzymatic decarboxylation of N^π^‐methyl‐, and N^τ^‐methyl‐L‐histidines (respectively) in a fully deuteriated incubation medium. The same decarboxylation carried out in a tritiated medium resulted in tritiated [αR‐^3^H]‐πMeHA and [αR‐^3^H]‐τMeHA isotopomers of N‐methylhistamine. Copyright © 2009 John Wiley & Sons, Ltd.

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