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Synthesis of nedocromil sodium labelled with tritium, deuterium and carbon-14

✍ Scribed by D J Wilkinson; W J S Lockley

Publisher: John Wiley and Sons
Year: 1985
Tongue: French
Weight: 337 KB
Volume: 22
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580220903

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✦ Synopsis

Nedocromil sodium labelled with carbon-14 has been prepared by a Claisen reaction between diethyl [ 1,2-14c]ethanedioate and methyl 6-ethanoyl-l-ethyl-l,4-dihydro-7- hydr xy-4-oxo-8-propylquinoli ne-2-carboxylate. The 2Hrhodium(II1) chloride catalysed exchange with the appropriate isotopically labelled water.

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