The synthesis of deuterium, tritium and carbon-14 labelled nicotinanilides
✍ Scribed by G. Ayrey; R. W. Dunlop; J. Duncan
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 367 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
The preparations of nicotin[2′,4′,6,‐^2^H~3~]anilide, 4′‐Cl‐nicotin[2′,6′‐^2^H~2~]anilide, 4′‐X‐nicotin[ar‐^3^H]anilide, (X = H−, CH~3~‐, Cl‐ or No~2~‐) and[6‐^14^C]nicotin[ar‐^3^H]anilide are described.
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## Abstract The synthesis of isotopomers of phenylpyruvic acid, PPA, selectively labeled with hydrogen isotopes in the 3‐position of the side‐chain is reported. Three deuterium or tritium labeled isotopomers of L‐phenylalanine, L‐Phe, i.e. [(3__S__)‐^2^H]‐L‐, [(3__S__)‐^3^H]‐L‐, and doubly labeled
## Abstract N‐[4‐]2‐(5‐Chloro ‐2‐methoxybenzamido) ethyl phenylsulfonyl N′ ‐cyclohexylurea, IXc, or glyburide, has been labeled with tritium and carbon‐ 14. The tritium label is located in the C‐3 position of the 5‐chloro ‐2‐methoxybenzoyl portion of the molecule, while the carbon‐14 label is incor