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Synthesis of carbon-14 and tritium labeled glyburide

✍ Scribed by R. S. P. Hsi

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
382 KB
Volume
9
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

N‐[4‐]2‐(5‐Chloro ‐2‐methoxybenzamido) ethyl phenylsulfonyl N′ ‐cyclohexylurea, IXc, or glyburide, has been labeled with tritium and carbon‐ 14. The tritium label is located in the C‐3 position of the 5‐chloro ‐2‐methoxybenzoyl portion of the molecule, while the carbon‐14 label is incorporated into the C‐2 position of the 2‐phenlethylamine moiety in the compound.

The specific activities of the tritium and carbon‐14 labeled products are 8.50 mCi/mM and 3.66 mCi/mM, respectively.

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