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Synthesis of tritium and carbon-14 labeled 1, 3-dioxolanes

✍ Scribed by Richard S. P. Hsi; Richard C. Thomas Jr.

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
328 KB
Volume
9
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Condensation of dimethoxdipheny Lmethane^14^C (III) with the levortatory (IIa) and dextrorotatory (IIb) isomers of 2‐(2‐piperidyl) ‐1, 2‐ethamediol hydrochloride, obtained respectively by hydrolysis from the d and 2 isomers (Ia and Ib) of the lower melting racemate of 2, 2‐diphenyl‐4‐(2‐piperidyl)‐1, 3‐dioxolane hydrochloride, produces the carbon‐14 labeled dioxolanee Ic and Id with retention of configruation at the asymetric carbon atoms. Stepwise reduction of 2,2‐dipheny 1‐4‐(1‐benzyl‐1‐2‐pyridy 1)‐1, 3‐dioxolane. The lower melting racemate was isolated as ists di‐tartaric acid salt (If) and resolved to give optically active tritium‐labeled dixolanes Ig and Ih.

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