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Synthesis of tritium and carbon-14 labeled 1,3-dioxolanes. II. D-2-ethyl-2-phenyl-4-(2-piperidyl)-1,3-dioxolane hydrochloride,

✍ Scribed by Richard S. P. Hsi

Publisher: John Wiley and Sons
Year: 1974
Tongue: French
Weight: 190 KB
Volume: 10
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2590100303

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✦ Synopsis

Abstract

The synthesis of ^3^H and ^14^C labeled d‐2‐ethyl‐2‐phenyl‐4‐(2‐piperidyl)‐1, 3‐dioxolane hydrochloride (Va and Vb respectively) is described. The optically pure α(‐)‐2‐(2‐piperidyl)ethane‐1,2‐diol hydrochloride (II), obtained by hydrolyzing α (+)‐2,2‐diphenyl‐4‐(2‐piperidyl)‐1,3‐dioxolane hydrochloride^(1)^ (I), is used as the starting material to minimize the need for separation of isomers in the products.

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