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Preparation of carbon-14 and tritium labeled d- and l-1, 1-diphenyl-2-methyl-3- aminopropanol hydrochloride

✍ Scribed by Richard C. Thomas

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
267 KB
Volume
15
Category
Article
ISSN
0022-2135

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✦ Synopsis

1 ,l -Oiphenyl-2-methyl-3-aminopropanol-1-"+C was prepared i n a five-step sequence o f reactions from "+C02 and resolved I n t o i t s d and 2 isomers i n an overall y i e l d o f 9.5% based on carbon-14. 1 ,l-Diphenyl-2-methyl-3-aminopropanol-3-~H was prepared by reduction o f an intermediate w l t h l i t h i u m aluminum t r i t i d e and resolved i n t o i t s d and Z isomers i n an overall y l e l d o f 7.3% based on tritium.

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