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A facile synthesis of pentadeuterated domiodol (2-iodomethyl-4-hydroxymethyl-1,3-dioxolane) from glycerol-1,1,2,3,3-d5

✍ Scribed by Patrizia Ferraboschi; Paride Grisenti; Enzo Santanitllo

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 177 KB
Volume: 34
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580340314

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✦ Synopsis

Abstract

The acid catalyzed reaction of glycerol‐d~5~ with bromoacetaldehyde dimethyl acetal affords the corresponding 2‐bromomethyl‐4‐hydroxymethyl‐1,3‐dioxolane, which was treated with lithium iodide in 2‐butanone to afford the pentadeuterated domiodol 1 in high isotopic purity.

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