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Synthesis of dopexamine hydrochloride labelled with tritium, deuterium and carbon-14

✍ Scribed by D J Wilkinson; W J S Lockley

Publisher: John Wiley and Sons
Year: 1987
Tongue: French
Weight: 360 KB
Volume: 24
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580241206

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✦ Synopsis

Dopexamlne hydrochloride labelled with carbon-14 has been prepared by a mixed anhydride reaction between 6-[ [ 2-( 3 , 4-d 1 me thoxypheny 1 ethyl] am ino ] -6-oxohexanoic acid. ethyl carbonochlorldate and 2-phenyl-[ l-'*C]ethylamine. Deuterium isotopomers have been prepared by exchange, reduction of an unsaturated precursor, and by reductive dehalogenation of a chloro-derivative. Tritium-labelled compound was obtained by acid-catalysed tritium exchange.

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