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Enzymatic synthesis of isotopomers of tyramine labeled with deuterium and tritium

✍ Scribed by Edyta Panufnik; Marianna Kañska

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
116 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

The combined chemical and enzymatic methods of synthesis of five isotopomers of l-tyrosine, l-Tyr, and their derivatives, i.e. corresponding isotopomers of tyramine (TA), labeled with deuterium and tritium have been reported. Two-step synthesis consists with introduction of deuterium or tritium label into intermediate l-Tyr using isotope exchange followed by enzymatic decarboxylation using enzyme tyrosine decarboxylase (EC 4.1.1.25). This way five isotopomers of l-tyrosine, i.e. [2-

-, [3 0 ,5 0 -2 H 2 ]-, [2 0 ,6 0 -2 H 2 ]-TA were obtained.

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