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Enzymatic synthesis of tritium-labelled isotopomers of L-DOPA

✍ Scribed by M. Kozłowska; R. Kański; M. Kańska

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
107 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

The synthesis of two isotopomers of l-DOPA labelled selectively with tritium is reported. In the intermediate step [3S-3 H]-, and [3 0 ,5 0 -3 H 2 ]-l-tyrosine, have been obtained using a combination of chemical and enzymatic methods. The labelled isotopomers of l-tyrosine, l-Tyr, have been converted into, [3S-3 H]-, and [5 0 -3 H]-l-DOPA using the enzyme mushroom tyrosinase (monophenol oxidase, EC 1.14.18.1) from Neurospora crassa.

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